1. The Exposome in an Epidemiological Context [15]
2. Concept
   1. Birth [16]
      1. The term exposome was coined by Dr Christopher Wild (Cancer Epidemiologist) in 2005. Exposome is a linguistic blend of Exposure + Genome. [16]
   2. Definition [1]
      1. "The cumulative measure of environmental influence and associated biological response throughout the lifespan of an individual including exposures from the environment, behavior, diet and endogenous processes."
      2. Simplified
         1. Total exposure (endogenous and exogenous) of an individual from conception till death.
   3. Utility
      1. Information gathered can indicate not only the link between an exposure and a disease but also provide insights into the mechanisms by which an exposure might be exerting its effects. Such insights may contribute to the weight of evidence in assigning causality to an exposure–disease association and open up avenues to prevention through modulation of specific identified biological pathways. [3]
      2. Exposomic data may contribute to determining why some people will develop a disease while other with the same or greater amount of exposure will not. [1]
   4. Composition [3]
      1. Internal [1]
         1. Internal factors are those that are specific to the individual such as age, body morphology, genome, metabolism, gut microflora, oxidative stress and aging (...)
      2. Specific External [1]
         1. Specific External factors include diet, occupational and environmental exposures (radiation, infectious agents, chemical contaminants) as well as physical (occupations), biological and physiological exposures (...)
      3. General External [1]
         1. General external factors include broader social constructs such as home location (climate, urban vs rural) education level and socioeconomic status, Psychological and mental stress (...)
      4. Visual Rendering
3. Strategies
   1. Facilitating Interdisciplinary connections [3]
   2. Stages of the Exposome [3]
   3. Identifying Common compounds in the Exposome [2]
   4. Identification Analysis of the Exposome [20]
      1. Structural Equations [18]
      2. Markov Chains [19]
      3. Causal Looping [17]
         1. Reinforcing Loop (positive feedback)
         2. Balancing loops (Negative feedback)
4. Measuring the Exposome
   1. Challenges [1]
      1. Analytical error measurements
      2. Reverse Causality
      3. Dynamicity
         1. Natural Exposomic Changes [3]
         2. Variability of exposure data
         3. variability over-time and between subjects
   2. Tools
      1. Biomarkers
         1. Definition
            1. Portmanteaux for biological marker : is a measurable indicator of some biological state or condition. [14]
         2. Utility
            1. Biomarkers can be use to assess the sustainability of the environmental conditions with respect to human health. [1]
      2. Field of Study
         1. Omics Biomarker
            1. Epigenetics [4]
            2. Transcriptomics [5]
            3. Proteomics [6]
            4. Metabolomics [7]
            5. Adductomics [8]
            6. Genomics [9]
         2. Molecular Epidemiology [10]
         3. Geographic information systems [11]
         4. Reality mining [12]
         5. Exposure Science [13]
         6. Human Biomarkers [2]
            1. Medium
            2. Blood
            3. Breath
            4. Urine
            5. Kinetic
            6. Absorption
            7. Distribution
            8. Metabolism
            9. Elimination
            10. Function
            11. Effect
            12. Suceptibility
            13. Exposure
            14. Origin
            15. Exogenous
            16. Endogenous
            17. Response
5. Sources