1. Basic
   1. HLDDR
   2. Young women
   3. Type 3 immune reaction
   4. UVB/UVA induced factor
2. Criteria
   1. M: Malar rash
   2. Discoid lupus erythematosus
   3. Serotitis
   4. oral ulcer
   5. Arthritis
   6. Photosensitivity
   7. B: Leukopenia, lymphopenia, thromobocytopenia and Anema
   8. R: Renal Disease
   9. A: ANA positive
   10. I: Immune disorder
   11. N: neurologic disease: otpic nerve, seizure, psychosis
   12. O: Other
3. Special feasure
   1. no Eosimophilia
   2. C3/C4 monitor activity
   3. Most common OPH: Reinalvasculitis wth infarction
   4. Most commone symptoms: Fatigue
   5. Life threatening of SLE
      1. GN
      2. CNS involvement
      3. Hemilytic anemia
4. Autoantibody
   1. Anti-dsDNA
      1. Lupus nephritis
   2. AntiSM
      1. Most specific to SLE
   3. Anti-RNP
      1. low risk of lupus nephritis
      2. related to
         1. Polymiositis
         2. scleroderma
         3. MCTD
   4. Anti-phospholipid ab
      1. DVT
      2. Habitual abortion
      3. CNS involvement
      4. Libman-Sache endocarditis
   5. Anti-Ro
      1. Dermatitis
      2. nephritis
      3. vasculitis
      4. Sicca
      5. Neonatal lupus
         1. Congenital heart block
   6. Anti-ribosomal P
      1. CNS SLE
   7. Anti-Histone
      1. Drug induced lupus
5. Treatment
   1. Supportive therapy
   2. NSAID
      1. Arthritis
      2. fever
      3. Serositis
      4. Don't use in active nephritis
   3. Hydroxychlroquine
      1. Skin rash, photosensitivity
      2. arthritis
      3. Malaise
      4. Useless for renal, CNS or hematologic problem
   4. Steroid
      1. Life threatening of SLE
         1. GN
         2. CNS involvement
         3. Hemilytic anemia
   5. Immunosuppressive agents
6. 4/11