1. Syllabus
2. methods of poisoning
   1. depression of CNS and breathing problems
   2. CV toxicity
      1. hypotension
      2. hypovolemia
      3. cardiac arrythmias--COCAINE
   3. body temperature regulation
      1. aspirin causes hyperthemia by uncoupling oxidative phosphorylation
      2. Subtopic 2
   4. cellular hypoxia
      1. CO
   5. seizures
   6. muscle hyperactivity/rigidity
      1. flaccid paralysis from nerve gase
   7. organ damage
3. Initial management
   1. ABCs
   2. DEXTROSE
   3. gastric lavage
4. Tx
   1. decontamination
   2. vomiting
      1. NOT FOR CORROSIVE COMPOUNDS OR PETROLEUM DISTILLATES
   3. activated charcoal
   4. cathartics
   5. whole bowel irrigation
   6. ADMINISTER SPECIFIC ANTIDOTE, if available
      1. for ex, use ammonium chloride to acidify urine
5. Chelating agents for heavy metals
   1. make metal non-ionic
   2. calcium disodium Edetate (EDTA)
      1. give by IV
      2. treat LEAD, CADMIUM, but NOT MERCURY
   3. dimercaperol
      1. give IM
      2. treat GOLD, ARSENIC, MERCURY, COPPER
   4. penicillamine
      1. treat COPPER in WILSON'S DISEASE