1. Adrenal Gland
   1. Adrenal Cortex
      1. zona glomerulosa
      2. zona fasciculata
      3. zona reticularis
   2. Adrenal Medulla
2. Aldosterone
3. Androgens
   1. DHEA
4. Anterior Pituitary
   1. FLAT PIG
      1. FSH
      2. LH
      3. ACTH
      4. TRH
      5. Prolactin
      6. Inhibin
      7. GH
5. Hypothalamus
   1. CRH
6. Stress
7. PLA2
8. Membrane phospholipids
9. Arachidonic Acid
10. Leukotrienes
11. LOX
12. Prostacyclin
13. Leukocyte modulation
14. Thromboxane
15. Prostaglandins
16. COX
17. Glucocorticoids
    1. Endogenous antiinflammatory = Cortisol
       1. Actions
          1. Elevates Lipocortin
       2. Duration of treatment
          1. Chronic
             1. Addison's adrenal insufficiency
             2. some Leukemias
          2. Acute
             1. Inflammation ( Rheumatoid Arthritis)
          3. If cell mediated inflammation
             1. Look for elevated Neutrophils
             2. Look for depreted Lymphocytes, Basophils,...
    2. Duration of Action 8-12h
       1. Hydrocortizone=Cortisol = 1
       2. Cortisone = 0.8
    3. Duration of Action 18-36h
       1. Methylprednisolone = 5
       2. Prednisolone=5
       3. Triansinolone=5
       4. Prednisone = 4
    4. Duration of Action 1-3d
       1. Betametazone=35 Activity
       2. Dexametazone=30 Activity
       3. Parametazone=10
18. NSAIDS