1. M1 + G ptn ~ ++PLC ~ ++IP3,DAG ~ ++Ca
2. M2 + Gi ~ --adenyl cyclase ~ --cAMP ~ ++K efflux ~ hyperpolarization
3. a1 + G ptn ~ ++PLC ~ ++IP3,DAG ~ ++Ca
4. M2 + Gi ~ --adenyl cyclase ~ --cAMP ~ (--NA release, --Ca)
5. b + Gs ~ ++adenyl cyclase ~ ++cAMP (++Ca)
6. Cholinergic Receptor
   1. Muscaranic
      1. M1
         1. CNS
         2. Autonomic ganglion
         3. Parietal Cell of Stomach
      2. M2
         1. CNS
         2. Heart
         3. Presynaptic cholinergic receptor
      3. M3
         1. CNS
         2. Smooth ms
         3. Secretory glands
   2. Nicotonic
      1. Nicotonic Neural (Nn)
         1. Autonomic ganglion
         2. Suprarenal medulla
      2. Neuromuscular (Nm)
         1. Motor end plate
7. Adrenegic Receptor
   1. Postsynaptic
      1. Alpha
         1. Alpha 1
            1. Mainly post-synaptic (generalized VC, active mydriasis)
         2. Alpha 2
            1. Pre-synaptic
            2. Post-synaptic
            3. CNS
            4. -- sym. flow from CNS
      2. Beta
         1. Beta 1
            1. Cardiac muscle (++heart, ++lipolysis)
         2. Beta 2
            1. Smooth muscle (bronchodilatation, VD)
         3. Beta 3
            1. ++Lipolysis ~ ++ c.FFA
            2. Selective agonist : Octopamine
   2. Presynaptic (Autoreceptor/CNS)
      1. stimulate a2:---release NA
      2. block a2:+++release NA
      3. stimulate b:+++release NA
      4. block b:---release NA