Isocitrate
is oxidized,
reducing
NAD+ to
NADH. Then
the resulting
compound
loses a CO2
molecule.
Citrate is
converted to
its isomer,
isocitrate, by
removal of
one water
molecule and
addition of
another
2x CoA-SH added
Another CO2
is lost, and the
resulting
compound is
oxidized,
reducing NAD+
to NADH.
The remaining molecule is
then attached
to coenzyme A
by an unstable
bond
Another CO2
is lost, and the
resulting
compound is
oxidized,
reducing NAD+
to NADH.
The remaining molecule is
then attached
to coenzyme A
by an unstable
bond
The substrate
is oxidized,
reducing NAD+ to
NADH and
regenerating
oxaloacetate.
+ H+
2x Acetyl CoA-SH
Addition of 2x Water
ATP
Citric Acid Cycle ( Krebs Cycle) in the mitochondria
Adding in of 2x CoA-SH
Pyruvate Dehydrogenase enzyme present
2x Pyruvate
Pyruvate is oxidized, with loss of its carboxyl group as CO2