1. Expression of virulence factors
2. physiological response
   1. cellular response
   2. vascular response
3. mechanical disruption
4. Functions
   1. prevents dessication
   2. maintains integrity
5. plaque
6. characteristics
   1. no clinical signs of inflammation
   2. pink
   3. scalloped
   4. knife-edged margins for most
   5. stippling
   6. firm
   7. presence of bacteria
7. characteristics
   1. no calculus
   2. redness of gingival margin
   3. swelling, shininess
   4. inflammatory cell infiltrates (15%)
   5. predominance of neutrophils and lymphocytes
   6. proliferation of basal cells of the epithelium downwards
   7. epithelial rete pegs invade the coronal portion of the lesion
8. characteristics
   1. predominance of T-lymphocytes
   2. increased number of plasma cells
   3. junctional epithelium substituted by pocket epithelium
   4. more permeable
   5. inflammatory cell infiltrate (50%)
   6. Subtopic 6
9. Adsorption of glycoproteins to tooth structure
   1. Pellicle Formation
      1. Adherence of primary colonizers
         1. Coaggregation of secondary colonizers
            1. Development of oxygen gradient
            2. shift from gram (+) to gram (-)
            3. Host response
            4. Early gingivitis
            5. Established gingivitis