1. Flunitrazepam(Rohypnol)- 'date rape' ; GHB - dissociation, euphoria, intoxication)
2. ALCOHOL & SEDATIVE, HYPNOTIC AND ANXIOLYTIC (benzos, barbi)
   1. INTOXICATION
      1. SLURRED SPEECH, incoordination, unsetady gaint, nystagmuc, imp of att and memory, stupor/ coma
   2. WITHDRAWAL
      1. -autonomic hyperactivity, inc hand tremors, insomnia, N&V, transcient hallu and illusions, psychomotor agitation, anxiety, grand mal seizures
3. STIMULANTS- AMPHETAMINES COCAINE, MDMA (ectasy)
   1. INTOXICATION
      1. Tachy/brady cardia, DILATED PUPILS, d/dx BP, perspiration. chills, n&v, wt loss, psychomotor agitation/retardation, muscular weakness/chest pain/arryth/respi deprn ; confusion.seizure, dyskinesia, dystonia, come
   2. WITHDRAWAL
      1. fatigue, VIVID UNPLEASANT DREAMS, insomnia/ hypersomnia / inc appetite , psychomotor agitation or retardation
4. CANNABIS
   1. INTOXICATION (within 2 hrs)
      1. CONJUNCTIVAL INJECTION, Inc appetite, dry mouth, tachy
   2. WITHDRAWAL
      1. ?doesn't cause withdrawal
5. OPOID
   1. INTOXICATION
      1. PUPILLARY CONSTRICTION (OR DILATATION due to anoxia from severe overdose)
      2. Drowsiness or coma, slurred speech, impairment in attention and memory
   2. WITHDRAWAL
      1. Dysphoric mood, N&V, muscle aches, LACRIMATION / RHINORRHEA, PUPILLARY DILATATION, PILOERECTION or sweating, diarrhoea, YAWNING, fever, insomnia
6. PHENCYCLIDINE
   1. INTOXICATION
      1. VERTICAL AND HORIZONTAL NYSTAGMUS, HT and tachy, NUMBNESS OR DEC RESPONSIVENESS TO PAIN, Ataxia, dysarthria, muscle rigidity, seizure, coma, HYPERACUSIS
7. HALLUCINOGENS (LSD,PCP, MUSHROOMS, KETAMINE)
   1. INTOXICATION
      1. PUPILS - DILATED, tachycardia, sweating, palpitation, blurred vision, tremors, inco-ordination
8. INHALANTS
   1. INTOXICATION
      1. Dizziness, nystagmus, incoordination, slurred speech, unsteady gait, lethargy, depressed reflexes, psychomotor retardation, tremor, gen muscle weakness, blurred vision / diplopia, stupor or coma, euphoria
9. CAFFAINE
   1. INTOXICATION
      1. Restlessness, nervousness, excitement, insomnia, flushed face, diuresis, GIT disturbance, muscle twitching, rambling flow or thgt and speech, tachy or arryth, periods of inexhaustibility, psychomotor agitation
10. NICOTINE
    1. WITHDRAWAL (within 24 hr)
       1. Dysphoric or depressed mood, insomnia. irritability, frustration or anger, anxiety, diff conc, restlessness, dec HR, inc appetite or wt gain.