1. Process
   1. DIR
      1. Safe
      2. Effective
      3. Easy to Use
   2. Design Exploration
   3. Specifications
      1. Physical Testing
      2. Vendor Research
      3. Physics Modeling
   4. Design Outputs
   5. Design Review
      1. Internal
      2. External
   6. Hyper critical
2. Elements
   1. IV Bag
      1. IV bag insulation
   2. Infusion Line Tubing (ILT)
      1. ILT Insulation
      2. ILT heat exchanger (ILT HX)
   3. Pump
   4. Sensors
      1. Temperature
      2. Pressure
      3. Bubble
      4. Flow
   5. Connectors
   6. Embedded System
      1. Monitor
      2. Control
3. Infusion Cooling Options
   1. Cool IV bag
      1. Cooling Process
         1. Active via Care Giver
            1. KettleBell Cooler
            2. ?
         2. Passive - Freezer / Refrigerator
            1. Portable - Small - In cathlab
            2. Community - Large
      2. Insulated IV bag
         1. Brrr-it0
         2. ?
      3. Insulated ILT
   2. Cool ILT
      1. Active via Heat Exchanger
         1. Short term < 60 min
         2. Flow rate ~ 30 ml/min
         3. Compact
         4. Integrate ILT
            1. Single Package
            2. Coupling
         5. Temperature control
            1. Active
            2. Pre-cooled
         6. Cost
            1. Low - disposable
            2. Medium - not disposable
      2. Insulated ILT
   3. Cool / Insulate Catheter
      1. Khione
      2. CoolGuide
         1. Early Work
         2. Redesign
      3. Alternative Thinking
         1. Rapid flow & diversion