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Pathology
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Vascular
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Functional Disorders
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Arhythmia
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Critical Care
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Shock
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Signs and symptoms
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Gastroenterology
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Signs and Symptoms
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Gastrointestinal
- Dysphagia
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Mouth
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Esophagus
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Functional Disturbances
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Signs and symptoms
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molecular biology of Cancer
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- Unknown primary site
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- Late consequence and treatment
- Hematology
-
Signs and symptoms
-
Anemia signs and symptoms
- 1.Glossitis(B12/folate)
- 2.Posterior column/lateral column corticospinal tract signs (B12 alone)
- 3. exercise intolerance
- 4.dyspnea
- 5.High outpus failure
- 6. koilonychia
- Polycythemia
- bleeding
- thrombosis
- lymph and spleen enlargement
- granulocytes and monocytes
-
Pathology
-
Peripheral blood pictures
- 1.Hypersegmented Neutrophil
- Causes:
- folate/B12 deficiency
- 2.microcytic, hypochromic cells
- RBC's that have increased pallor can be assumed to be microcytic
- Causes:
- Iron deficiency
- anemia of chronic disease (ACD)
- Thalassemia
- Sideroblastic Anemia
- 3. Sickle cells ( anemia not trait)
- 4. Target cells
- Causes:
- Alcoholic liver disease
- hemoglobinopathy
- 5.Spherocytes
- Def.: No Central Area of Pallor
- Causes:
- Congenital spherocytosis
- ABO hemolytic disease of newborn
- 6. Tear drop
- Causes:
- myelofibrosis
- thalassemia
- 7.Howel Jolly body
- Causes:
- Spleen surgically removed
- Sysfunctional spleen as in HbS disease
- 8.Platelet
- small, red, anucleate
- 9.Lymphocyte
- black dot with thin rim of cytoplasm
- 10.Auer rod
- myeloblast with immature nucleus and splinter-like structure in cytoplasm
- 11.atypical lymphocyte
- Def.: big cell with a lot of blue cytoplasm
- Causes:
- Infectious Mononucleosis
- CMV
- Toxoplasmosis
- viral hepatitis
- phenytoin
- 12.eosinophil
- large, red granules that don't cover the nucleus and are the same color as RBC's
- Causes:
- type I hypersensitivity
- invasive helminthic infections
- 13.basophil
- Large, purple granules that do cover the nucleus and granules are darker than RBC's
- Causes: myeloproliferative diseases
- 14.rouleau
- Are simply RBC's with stack of coins effect: see increased sedimentation rate
- 15.schistocytes
- are fragmented RBC's seen in:
- microangiopathic hemolytic anemias:
- TTP
- HUS
- DIC
- 16.reticulocyte
- Special supravital stain: thin filaments represent RNA
- Are increased in:
- hemolytic anemias
- 5-7d after blood loss
- Iron deficienty after treatment
- B12/folate deficiency
- 17.Heinz bodies
- special stain: large blue inclusions with RBC membranes
- seen in G6PD deficiency
- 18.coarse basophilic stipling
- routine stain sees ribosomes
- seen in Lead poisoning
- Blood
- Smear
- Leukemias
- CML
- CLL
- Acute Leukemia
-
Bone marrow pictures
- 1.megaloblastic marrow
- all cells appear big due to large, immature nuclei ( giant band neutrophils)
- Cause: B12/folate deficiency
- 2.myelofibrosis
- marrow is composed of fibrous tissue ( large cells are megakaryocytes)
- 3.aplastic anemia
- empty marrow with fat and islands of lymphocytes
- 4.multiple myeloma
- plasmablasts with bright blue cytoplasm, eccentric Nuclei, perinuclear halo
- 5.ringed sideroblast
- Prussian blue stain for iron: ring of blue around the nucleus of normoblast
- Indicate a defect in heme synthesis:
- Sideroblastic anemias due to Alcohol, pyridoxine, Lead poisoning
- Pathology
- Bone Marrow
- Follicular Lymphoma
- Follicular Lymphoma.2
- Erythroid hyperplasia
- Adenocarcinoma metastatic to bone
- Adenocarcinoma metastatic to bone
- Chronic Idiopathic myelofibrosis
- Blood
- CML
- CLL
- Acute Leukemia
-
Hematology
-
myeloproliferative disease
- polycythemia vera
- hematopoietic transplantation
-
RBC's
- Anemia
- Anemia signs and symptoms
- 1.Glossitis(B12/folate)
- 2.Posterior column/lateral column corticospinal tract signs (B12 alone)
- 3. exercise intolerance
- 4.dyspnea
- 5.High outpus failure
- 6. koilonychia
- Classification of Anemia by MCV
- Microcytic MCV<80
- Iron deficiency
- Sideroblastic Anemia
- Alcoholics, B6 deficiency, Pb poisoning, preleukemia syndromes
- Lead poisoning
- Anemia of Chronic Disease
- Thallasemia
- Normocytic MCV 80-100
- Corrected reticulocyte under 2%
- Acute blood loss
- Acute iron deficiency
- Anemia of chronic disease
- Renal disease
- Corrected reticulocyte more than 3%
- Intrinsic hemolytic anemia = something wrong with RBC ( structure, biochem)
- Membrane defects
- Congenital spherocytosis or elliptocytosis
- Paroxysmal nocturnal hemoglobinuria
- Abnormal hemoglobins
- Sickle cell
- Deficient enzymes
- G6PD
- Pyruvate kinase deficiency
- Extrinsic hemolytic anemia ( RBC is normal)
- Autoimmune hemolytic anemias
- Microangiopathic hemolytic anemia
- blood loss for more than a week
- Macrocytic MCV>100
- Folate deficiency=MC
- B12 deficiency
- 1.hypoproliferative anemias
- 2.Ineffective erythropoiesis anemias
- 3. hemolytic/blood loss anemia
- hemoglobinopathies
- megaloblastic
- myelodysplastic, aplastic, bone marrow failure
- Hemostasis
- platelet and vessel wall disorders
- coagulation and thrombosis
- antiplatelet, anticoagulant, fibrinolytic therapy
- Erythrocytosis
-
WBC's
- lymphoid cell cancer
- Lymphomas
- Leukemia
- myeloid
- acute
- chronic
- Subtopic 2
- plasma cell disorders
- Hematopathology
- Rheumatology
-
Infectious Disease
-
Basic Science
- Immunization and Travel
- The Acutely Ill Febrile Patient
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Community Acquired
- Infective Endocarditis
- Osteomyelitis
- Intraabdominal infections
- Diarrheal disease and bacterial food poisoning
- Sexually Transmitted disease
- Clostridium dificile associated
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Nosocomial Infections
- Hospital infections
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Bacteria
- prophylaxis and treatment
- Gm+
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- Nocardia
- Actinomycosis
- Mixed anaerobic
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Mycobacteria
- Pharmacology
- Tuberculosis
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Spirochetes
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Viruses
- Basic Science
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DNA viruses
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DNA/RNA respiratory viruses
- SARS
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RNA viruses
- Retrovirus
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- OTHER
- viral gastroenteritis
- enteroviruses and Reoviruses
- Rubeola = Measles
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Fungi
- Diagnosis
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Protozoa
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RBC parasites
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Helminths
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Nematodes
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Trematodes
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Genetics
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Nutrition
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Overdosing and Toxicology
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Kidney and Urinary tract
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Signs and Symptoms
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Renal and Urinary tract
- Acidosis and Alkalosis
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Pathology
- Acute Renal Failure
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Immune system
- Basic Science
- Primary Immune Deficiencies
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Immune-mediated injury
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Autoimmunity
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Connective tissues
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- Osteoarthritis
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Arthritis associated with systemic diseases
- Fibromyalgia
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Dermatology
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Signs and symptoms
- approach
- Eczema
- Psoriasis
- infections
- manifestations of internal disease
- immunologically mediated disorders of skin
- cutaneous drug reactions
- photosensitivity
- Ophthalmology