1. TFs without mutation vs. TF with mutation
   1. all mutations
      1. identify 2 groups of TFs
      2. result
   2. functional mutations
      1. identify 2 groups of TFs
      2. result
2. Expression datasets
   1. age series data
   2. exon array data: 4 tissues
      1. summarize gene expression
3. Identify interseting TFs with aa mutations