1. adverse effects
   1. myelosupression
   2. hepatotoxicity
      1. cirrhosis
      2. other liver disease
      3. fibrosis
   3. overwhelming sepsis
   4. pneumocytis
   5. mucositis
   6. alopecia
   7. GI disturbances
   8. rash
   9. injection site reaction
   10. nausea
   11. intolerance
   12. anemia
   13. infection
       1. bacterial
       2. fungal
       3. viral
       4. mycobacterial
   14. leukopenia
   15. neutropenia
2. data to pull
   1. history and examination
      1. fever
      2. nausea
      3. constituational
      4. Pulmonary
         1. shortness of breath
         2. cough (new onset)
      5. skin and integument
         1. bruising
         2. mouth ulcers
         3. rash
      6. HEENT
      7. extremities
         1. oedema
      8. GI
         1. diarrhea
         2. vomiting
      9. reproductive
         1. pregnancy
      10. malaise
      11. fatigue
   2. examination
   3. radiograph
      1. chest x-ray
   4. laboratory tests
      1. FBC
      2. LFTs
         1. alanine aminotransferase (AST)
         2. aspartate aminotransferase (AST)
      3. creatinine
      4. hepatitis B and C
   5. risk factors
      1. use of antifolate agents such as trimethoprim
      2. presence of folate deficiency
      3. renal insufficiency
      4. prior history of hepatitis B or C
      5. obesity
      6. diabetes
      7. alcohol intake
      8. preexisting lung damage
      9. age
      10. of child bearing potential
          1. inadequate use of contraception
      11. prior history of liver disease
          1. liver disease associated with alcohol intake