1. HISTAMINES
   1. H1
      1. Allergy Inflammation Stimulates RAS Promotes Wakefulness
         1. 1st Gen:
            1. crosses BBB ACH receptor
            2. USED IN Motion sickness drig induced PARKINSONISM
         2. 2nd Gen:
            1. do not cross BBB no Ach receptor
            2. used in Allergy
   2. H2
      1. Stomach
   3. H3
      1. PreSynaptic
   4. H4
      1. WBC
2. AUTOCOIDS
   1. Amine Autocoids
      1. Histamines
      2. Serotonin
   2. Lipid Derived
      1. Prostaglandin Leukotrines Platelet Activating Factors
   3. Peptide autocoids
      1. Plasma Kinins Angiotensin
   4. Others
      1. Gastric Autocoids Cytokines
3. DRUGS FOR BRONCHIAL ASTHMA
   1. Bronchodilators
      1. Symphathomimetics
         1. with â & ß effect
            1. Adrenaline Ephedrine
         2. with ß effects
            1. Isoprenaline
         3. with ß2 effect
            1. Salbutamol Salmeterol Terbutaline
      2. Theophyllines
      3. Anticholinergics
         1. Ipatropium Bromide Atropine Methonitrate
   2. Leukotrine Antagonists
      1. Zileuton
      2. Montelucast
   3. AntiHistaminics
      1. Ketotifen
   4. Corticosteroids
      1. Systemic
         1. Hydrocortisone prednisolone
      2. Inhalational
         1. Beclamethasone
4. DRUGS USED IN COUGH
   1. Pharyngeal demulcents
      1. lozenges
      2. Syrup
      3. Glycerine
   2. Expectorants
      1. Secretion enhancers
         1. Pot. Citrate
         2. Pot. Iodide
         3. Ammonium Chloride
      2. Mycolytics
         1. bromhexine
         2. Acetyl cysteine
   3. Antitussives
      1. Opoids
         1. Codiene
         2. Ethyl Morphine
      2. Non opoids
         1. Noscapine
         2. Dexomethorphan
      3. Antihistamines
         1. Chlorpheniramine
         2. Diphenhydramine
         3. Promethazine
      4. Pulmonary Receptor desensitizers
         1. Prenoxdiazine
   4. Ajduvant Antitussive
      1. Bronchodilators
         1. Salbutamol
         2. Terbutaline
5. MANAGEMENT OF STATUS ASTHMATICUS
   1. Humidified Oxygen Inhalation
      1. 2-6Lts/min O2 to reach 90% saturation level.
   2. Nebulization
      1. ß2 Agonist
         1. Salbutamol 5mg/ Terbutaline 10 mg
      2. Anticholinergics
         1. Ipratropium Bromide 0.5 mg
   3. Systemic Glucocorticoids
      1. IV Hydrocortisone 200mg STAT
   4. IV Infusion
      1. Aminophylline
      2. MgSo4 1-2 gm over 20 mins.
   5. Mechanical Ventilation
6. NSAIDS
   1. Nonselective COX inhibitors (Traditional NSAIDS)
      1. Salicylates
         1. Aspirin
      2. Propionic acid derivatives
         1. Ibuprofen
      3. Anthranilic acid derivative
         1. Mephenamic acid
      4. Aryl-acetic acid derivatives
         1. Diclofenac
         2. Aceclofenac
      5. Oxicam derivatives
         1. Piroxicam
         2. Tenoxicam
      6. Pyrrolo-pyrrole derivative
         1. Ketorolac
      7. Indole derivative
         1. Indomethacin
   2. Preferential COX-2 inhibitors
      1. Nimesulide
      2. Meloxicam
      3. Nabumetone
   3. Selective COX-2 inhibitors
      1. Celecoxib
      2. Etoricoxib
      3. Parecoxib
   4. Analgesic-antipyretics with poor antiinflammatory action
      1. Paraaminophenol derivative
         1. Paracetamol (Acetaminophen)
      2. Pyrazolone derivatives
         1. Metamizol (Dipyrone)
         2. Propiphenazone
      3. Benzoxazocine Derivative
         1. Nefopam
7. Prostaglandins
   1. PDG2
      1. Smooth Muscle Contraction/Relaxation
      2. Inhibition of platelet aggregation
   2. PGE2
      1. Regulation of Bone Formation and resorption
   3. PGI2
      1. Inhibition of Platelet aggregation
      2. Effective vasodilation
   4. THROMBOXANE
      1. Effective vasoconstriction
      2. hypertensive agent